Cat. No. 2748
Chemical Name: 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-
Biological ActivitySelective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Haggerty et al (2000) Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis. Chem.Biol. 7 275. PMID: 10780927.
Ohta et al (2001) Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779. Inflamm.Res. 50 544. PMID: 11766994.
Kaila et al (2007) Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J.Med.Chem. 50 21. PMID: 17201408.
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Keywords: KF 38789, supplier, Selective, inhibitors, P-selectin-mediated, cell, adhesio, Adhesion, Molecules, KF38789
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March 28 - April 1, 2015