Cat. No. 1589
Chemical Name: (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e]benzoxacyclotetradecin-6,12(7H)-dione
Biological ActivityAntifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Oikawa et al (1993) Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur.J.Pharmacol. 241 221. PMID: 7694864.
Schulte et al (1999) Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol.Endocrinol. 13 1435. PMID: 10478836.
Lee et al (2002) Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol.Cell.Endocrinol. 188 47. PMID: 11911945.
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Keywords: Radicicol, supplier, Hsp90, inhibitors, Antifungal, antibiotics, Heat, Shock, Proteins, 90
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