R&D Systems Inc. Tocris Bioscience Boston Biochem

Radicicol

Cat. No. 1589

Radicicol C18H17ClO6 [12772-57-5]

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Chemical Name: (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione

Biological Activity

Antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.

Technical Data

M.Wt:
364.78
Formula:
C18H17ClO6
Solubility:
Soluble to 25 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
12772-57-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Oikawa et al (1993) Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur.J.Pharmacol. 241 221. PMID: 7694864.

Schulte et al (1999) Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol.Endocrinol. 13 1435. PMID: 10478836.

Lee et al (2002) Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol.Cell.Endocrinol. 188 47. PMID: 11911945.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Radicicol, supplier, Hsp90, inhibitors, Antifungal, antibiotics, Heat, Shock, Proteins, 90

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