R&D Systems Inc. Tocris Bioscience Boston Biochem

Radicicol

Cat. No. 1589

Radicicol C18H17ClO6 [12772-57-5]

Price and Availability

For Radicicol pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione

Biological Activity

Antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.

Technical Data

M.Wt:
364.78
Formula:
C18H17ClO6
Solubility:
Soluble to 25 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
12772-57-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Oikawa et al (1993) Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur.J.Pharmacol. 241 221. PMID: 7694864.

Schulte et al (1999) Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol.Endocrinol. 13 1435. PMID: 10478836.

Lee et al (2002) Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol.Cell.Endocrinol. 188 47. PMID: 11911945.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Radicicol, supplier, Hsp90, inhibitors, Antifungal, antibiotics, Heat, Shock, Proteins, 90

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Parkinson's Disease: Neurobiology and Therapeutic Strategies

Written by Anthony H.V. Schapira

Parkinson's Poster

'Updated in 2014 - this poster summarizes the neurobiology of Parkinson's Disease (PD), including new genetic insight, neurotransmitter pathways, and the role of aberrant α-synuclein metabolism in PD pathogenesis.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

EC 144

High affinity, potent and selective Hsp90 inhibitor

TRC 051384

Inducer of heat shock protein Hsp70

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.