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GYKI 53655 hydrochloride

Cat. No. 2555

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Chemical Name: 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride

Biological Activity

Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl₂- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC₅₀ = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC₅₀ = 32 μM) at high concentrations.

Technical Data

M.Wt:

388.85

Formula:

C₁₉H₂₀N₄O₃.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

143692-48-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Paternain et al (1995) Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 14 185. PMID: 7826635.

Szabados et al (2001) Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res.Bull. 55 387. PMID: 11489346.

Perrais et al (2009) Antagonism of recombinant and native GluK3-containing kainate receptors. Neuropharmacology 56 131. PMID: 18761361.

If you know of a relevant citation for this product please let us know.

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Keywords: GYKI 53655 hydrochloride, supplier, GYKI53655, hydrochloride, non-competitive, AMPA, receptors, kainate, antagonists, GluK3

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