Cat. No. 2722
Alternative Name: Chromogranin A344-364
Biological ActivityNon-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Mahata et al (1997) Novel autocrine feedback control of catecholamine release. J.Clin.Invest. 100 1623. PMID: 9294131.
Mahata et al (2000) Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A344-364): identification of amino acid residues crucial for activity. Mol.Endocrinol. 14 1525. PMID: 11043569.
Kruger et al (2003) Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. Regul.Peptides 114 29.
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Keywords: Catestatin, supplier, Non-competitive, nicotinic, cholinergic, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Chromogranin, A344-364, A344364