R&D Systems Inc. Tocris Bioscience Boston Biochem

Catestatin

Cat. No. 2722

Catestatin Arg-Ser-Met-Arg-Leu-Ser-Phe-Arg-Ala-Arg-Gly-Tyr-Gly-Phe-Arg-Gly-Pro-Gly-Leu-Gln-Leu

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Alternative Name: Chromogranin A344-364

Biological Activity

Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.

Technical Data

M.Wt:
2425.84
Formula:
C107H173N37O26S
Sequence:
RSMRLSFRARGYGFRGPGLQL
Solubility:
Soluble to 2 mg/ml in 10% acetonitrile
Storage:
Store at -20°C
CAS No:
142211-96-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Mahata et al (1997) Novel autocrine feedback control of catecholamine release. J.Clin.Invest. 100 1623. PMID: 9294131.

Mahata et al (2000) Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A344-364): identification of amino acid residues crucial for activity. Mol.Endocrinol. 14 1525. PMID: 11043569.

Kruger et al (2003) Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. Regul.Peptides 114 29.

If you know of a relevant citation for this product please let us know.

Keywords: Catestatin, supplier, Non-competitive, nicotinic, cholinergic, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Chromogranin, A344-364, A344364

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