Cat. No. 2722
Alternative Name: Chromogranin A344-364
Biological ActivityNon-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Mahata et al (1997) Novel autocrine feedback control of catecholamine release. J.Clin.Invest. 100 1623. PMID: 9294131.
Mahata et al (2000) Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A344-364): identification of amino acid residues crucial for activity. Mol.Endocrinol. 14 1525. PMID: 11043569.
Kruger et al (2003) Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. Regul.Peptides 114 29.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Catestatin, supplier, Non-competitive, nicotinic, cholinergic, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Chromogranin, A344-364, A344364
Find multiple products by catalog number
New Products in this Area
Allosteric agonist at α7 nAChRA 85380 dihydrochloride
High affinity and selective α4β2 agonistCC4
High affinity and subtype-selective α6β2 and α4β2 partial agonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.