Co 102862

Cat. No. 2642

Co 102862 C14H12FN3O2 [181144-66-1]

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Alternative Name: V102862

Chemical Name: 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide

Biological Activity

Broad spectrum, state-dependent blocker of voltage-gated sodium channels. Displays ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Anticonvulsant; displays activity in rodent models of tonic/clonic and partial-complex seizures.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Ilyin et al (2005) V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Br.J.Pharmacol. 144 801. PMID: 15778702.

Ilyin et al (2006) Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states. J.Pharmacol.Exp.Ther. 318 1083. PMID: 16728593.

If you know of a relevant citation for this product please let us know.

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Keywords: Co 102862, supplier, State-dependent, Na+, channel, blockers, anticonvulsant, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Co102862, Voltage-gated Sodium (NaV) Channel Blockers

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