Cat. No. 1588
Alternative Name: Lu 19-005
Chemical Name: (1R,3S)-rel-3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride
Biological ActivityPotent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenalin (NET) (Ki values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Hyttel and Larsen (1985) Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline and serotonin. J.Neurochem. 44 1615. PMID: 2580950.
Negus et al (1999) Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. J.Pharmacol.Exp.Ther. 291 60. PMID: 10490887.
Gu et al (2000) Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J.Med.Chem. 43 4868. PMID: 11123996.
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Keywords: Indatraline hydrochloride, supplier, Potent, noradrenalin, noradrenaline, reuptake, inhibitors, inhibits, 5-HT, dopamine, Noradrenalin, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, DAT, Dopamine, Serotonin, SERT, 5-Hydroxytryptamine, Lu19-005
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