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Indatraline hydrochloride

Cat. No. 1588

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Alternative Name: Lu 19-005

Chemical Name: (1R,3S)-rel-3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride

Biological Activity

Potent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenalin (NET) (K_i values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.

Technical Data

M.Wt:

328.67

Formula:

C₁₆H₁₅Cl₂N.HCl

Solubility:

Soluble to 25 mM in water

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

86939-10-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Hyttel and Larsen (1985) Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline and serotonin. J.Neurochem. 44 1615. PMID: 2580950.

Negus et al (1999) Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. J.Pharmacol.Exp.Ther. 291 60. PMID: 10490887.

Gu et al (2000) Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J.Med.Chem. 43 4868. PMID: 11123996.

If you know of a relevant citation for this product please let us know.

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Keywords: Indatraline hydrochloride, supplier, Potent, noradrenalin, noradrenaline, reuptake, inhibitors, inhibits, 5-HT, dopamine, Noradrenalin, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, DAT, Dopamine, Serotonin, SERT, 5-Hydroxytryptamine, Lu19-005

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