Cat. No. 2705
Alternative Name: R-75251
Chemical Name: 5-[(3-Chlorophenyl)-1H-imidazol-1-y
Biological ActivityCytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Van Wauwe et al (1992) Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. J.Pharmacol.Exp.Ther. 261 773. PMID: 1374473.
Njar et al (2006) Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases. Bioorg.Med.Chem. 14 4323. PMID: 16530416.
Goss et al (2007) Effects of liarozole fumarate (R85246) in combination with tamoxifen on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model. BMC Cancer 7 26. PMID: 17266767.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Liarozole hydrochloride, supplier, Cytochrome, P450, CYP26, inhibitors, blocks, retinoic, acid, metabolism, Blocks, RXR, Retinoid, X, Receptors, CYP, RAR, RAMBA, Retinoic, Acid, R75251
Find multiple products by catalog number
New Products in this Area
Pregnane X receptor agonist; antibioticS 07662
Inverse agonist of the constitutive androstane receptor (CAR)Bazedoxifene acetate
Potent and selective estrogen receptor modulator (SERM)Paricalcitol
Analog of the active form of vitamin D2
April 12 - 15, 2015