Cat. No. 2646
Chemical Name: N-(4-[(-3-Chloro-4-fluorophenyl)ami
Biological ActivityPotent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2 respectively). Inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 values are 2.5 and 24 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Klutchko et al (2006) Tyrosine kinase inhibitors. 19. 6-alkynamides of 4-anilinoquinazolines and 4-aniliopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J.Med.Chem. 49 1475. PMID: 16480284.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: HDS 029, supplier, Potent, inhibitors, ErbB, receptor, family, Epidermal, Growth, Factors, Receptors, Her, EGFR, Receptor, Tyrosine, Kinases, RTKs, HDS029
Find multiple products by catalog number
New Products in this Area
Highly potent HGF/c-MET inhibitor; also AT4 antagonistAEE 788
Potent EGFR and VEGFR inhibitorXL 184
Potent VEGFR inhibitor; also inhibits other RTKsPKI 166 hydrochloride
Potent EGFR-kinase inhibitorASP 3026
Potent anaplastic lymphoma kinase (ALK) inhibitorKYL
EphA4 receptor tyrosine kinase inhibitor; neuroprotectivePD 90780
Inhibits NGF binding to p75NTRLM11A 31 dihydrochloride
Nonpeptide p75NTR ligand; neuroprotectiveEG 00229
Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
April 13 - 15, 2015