Cat. No. 2677
Chemical Name: 7-Amino-4-chloro-3-methoxy-1H-2-ben
Biological ActivityInhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC50 ~ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Petit et al (2001) New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage. Nat.Cell.Biol. 3 507. PMID: 11331880.
Petit et al (2003) JLK isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo. J.Neurosci.Res. 74 370. PMID: 14598313.
Hellstrom et al (2007) DII4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445 776. PMID: 17259973.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: JLK 6, supplier, inhibitors, γ-secretase, gamma-secretase, mediated, βAPP, betaAPP, processing, Proteinases, Proteases, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, beta, Peptides, JLK6, amyloidbeta, amyloidb, amyloidβ
Find multiple products by catalog number
New Products in this Area
Broad spectrum DUB inhibitorTC-E 5007
Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitorSD 2590 hydrochloride
Potent MMP inhibitorAliskiren hemifumarate
Potent renin inhibitor; antihypertensive
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.