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JLK 6

Cat. No. 2677

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Chemical Name: 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran

Biological Activity

Inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC₅₀ ~ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β.

Technical Data

M.Wt:

225.63

Formula:

C₁₀H₈ClNO₃

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

62252-26-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Petit et al (2001) New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage. Nat.Cell.Biol. 3 507. PMID: 11331880.

Petit et al (2003) JLK isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo. J.Neurosci.Res. 74 370. PMID: 14598313.

Hellstrom et al (2007) DII4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445 776. PMID: 17259973.

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Keywords: JLK 6, supplier, inhibitors, γ-secretase, gamma-secretase, mediated, βAPP, betaAPP, processing, Proteinases, Proteases, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, beta, Peptides, JLK6