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Moexipril hydrochloride

Cat. No. 2691

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Alternative Name: RS 10085

Chemical Name: 2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid hydrochloride

Biological Activity

Angiotensin-converting enzyme (ACE) inhibitor that is hydrolyzed in the liver to the active metabolite moexiprilat (IC₅₀ values are 2.1 and 2700 nM for moexiprilat and moexipril respectively). Antihypertensive; decreases mean blood pressure in the spontaneous hypertensive rat (SHR). Also blocks degradation of bradykinin into inactive metabolites.

Technical Data

M.Wt:

535.03

Formula:

C₂₇H₃₄N₂O₇.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

82586-52-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Edling et al (1995) Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril. J.Pharmacol.Exp.Ther. 275 854. PMID: 7473177.

Friehe and Ney (1997) Pharmacological and toxicological studies of the new angiotensin converting enzyme inhibitor moexipril hydrochloride. Arzneim.-Forsch. 47 132.

Chrysant and Chrysant (2004) Pharmacological and clinical profile of moexipril: a concise review. J.Clin.Pharmacol. 44 827. PMID: 15286086.

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