Cat. No. 2691
Alternative Name: RS 10085
Chemical Name: 2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)
Biological ActivityAngiotensin-converting enzyme (ACE) inhibitor that is hydrolyzed in the liver to the active metabolite moexiprilat (IC50 values are 2.1 and 2700 nM for moexiprilat and moexipril respectively). Antihypertensive; decreases mean blood pressure in the spontaneous hypertensive rat (SHR). Also blocks degradation of bradykinin into inactive metabolites.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Edling et al (1995) Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril. J.Pharmacol.Exp.Ther. 275 854. PMID: 7473177.
Friehe and Ney (1997) Pharmacological and toxicological studies of the new angiotensin converting enzyme inhibitor moexipril hydrochloride. Arzneim.-Forsch. 47 132.
Chrysant and Chrysant (2004) Pharmacological and clinical profile of moexipril: a concise review. J.Clin.Pharmacol. 44 827. PMID: 15286086.
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Keywords: Moexipril hydrochloride, supplier, Angiotensin-converting, enzyme, ACE, inhibitors, Proteinases, Proteases, RS10085
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