Cat. No. 2689

POM 1 H2O40Na6W12 [12141-67-2]

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Alternative Name: Sodium polyoxotungstate

Chemical Name: Sodium metatungstate

Biological Activity

Inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet


Muller et al (2006) Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg.Med.Chem.Lett. 16 5943. PMID: 16997558.

Grenz et al (2007) Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 21 2863. PMID: 17442731.

Wall et al (2008) The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. 55 1251. PMID: 18768144.

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Keywords: POM 1, supplier, inhibitors, E-NTPDases, ATPases, POM1, NTPDase Inhibitors

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