R&D Systems Inc. Tocris Bioscience Boston Biochem

CL 82198 hydrochloride

Cat. No. 2632

CL 82198 hydrochloride C17H23N2O3.HCl [1188890-36-9]

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Chemical Name: N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride

Biological Activity

Selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.

Technical Data

M.Wt:
338.83
Formula:
C17H23N2O3.HCl
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1188890-36-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648.

Borg et al (2003) IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr. 5 122.

If you know of a relevant citation for this product please let us know.

Keywords: CL 82198 hydrochloride, supplier, Selective, inhibitors, MMP-13, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, CL82198, hydrochloride

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