CL 82198 hydrochloride

Cat. No. 2632

CL 82198 hydrochloride C17H23N2O3.HCl [1188890-36-9]

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Chemical Name: N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride

Biological Activity

Selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.

Technical Data

Soluble to 100 mM in water and to 75 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648.

Borg et al (2003) IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr. 5 122.

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Keywords: CL 82198 hydrochloride, supplier, Selective, inhibitors, MMP-13, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, CL82198, hydrochloride, Matrix Metalloprotease Inhibitors

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