R&D Systems Inc. Tocris Bioscience Boston Biochem

Pifithrin-μ

Cat. No. 2653

Pifithrin-mu C8H7NO2S [64984-31-2]

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Alternative Name: NSC 303580

Chemical Name: 2-Phenylethynesulfonamide

Biological Activity

Inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.

Technical Data

M.Wt:
181.21
Formula:
C8H7NO2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
64984-31-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Strom et al (2006) Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat.Chem.Biol. 2 474. PMID: 16862141.

Kawamura et al (2009) Linking the p53 tumor suppressor pathway to somatic cell reprogramming. Nature 460 1140. PMID: 19668186.

Leu et al (2009) A small molecule inhibitor of inducible heat shock protein 70 (HSP70). Mol.Cell 36 15. PMID: 19818706.

Steele et al (2009) 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood 114 1217. PMID: 19515722.

If you know of a relevant citation for this product please let us know.

Keywords: Pifithrin-mu, supplier, inhibitors, p53-mitochondrial, binding, Transcription, Factors, MDM2, p14ARF, Pifithrin-mu, NSC303580

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