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Marimastat

Cat. No. 2631

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Alternative Names: BB 2516, Marimistat

Chemical Name: (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide

Biological Activity

Broad spectrum inhibitor of MMPs (IC₅₀ values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.

Technical Data

M.Wt:

331.41

Formula:

C₁₅H₂₉N₃O₅

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at -20°C

CAS No:

154039-60-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Rasmussen and McCann (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol.Ther. 75 69. PMID: 9364582.

Wada et al (2003) Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition. Clin.Exp.Metastasis 20 431. PMID: 14524532.

Bjornland et al (2005) Matrix metalloproteinases participate in osteosarcoma invasion. J.Surg.Res. 127 151. PMID: 16083752.

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Keywords: Marimastat, supplier, Broad, spectrum, MMP, inhibitors, Matrix, Metalloprotease, Matrixins, Metalloproteinase, proteinases, proteases, BB2516