Cat. No. 2631
Alternative Names: BB 2516, Marimistat
Chemical Name: (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
Biological ActivityBroad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Rasmussen and McCann (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol.Ther. 75 69. PMID: 9364582.
Wada et al (2003) Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition. Clin.Exp.Metastasis 20 431. PMID: 14524532.
Bjornland et al (2005) Matrix metalloproteinases participate in osteosarcoma invasion. J.Surg.Res. 127 151. PMID: 16083752.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Marimastat, supplier, Broad, spectrum, MMP, inhibitors, Matrix, Metalloprotease, Matrixins, Metalloproteinase, proteinases, proteases, BB2516
Find multiple products by catalog number
New Products in this Area
Dipeptidyl peptidase II (DPP-II) inhibitorVialinin A
Inhibitor of USP4 and USP5/IsoTMI 2 (MALT1 inhibitor)
MALT1 inhibitorNSC 687852
Inhibitor UCHL5 and USP14GI 254023X
Selective ADAM10 metalloprotease inhibitorGM 6001
Broad-spectrum MMP inhibitorNSC 405020
Inhibitor of MT1-MMP; antitumor
Win a Kindle
December 14 - 18, 2013
New Orleans, USA