Marimastat

Cat. No. 2631

Marimastat C15H29N3O5 [154039-60-8]

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Alternative Names: BB 2516, Marimistat

Chemical Name: (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide

Biological Activity

Broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.

Technical Data

M.Wt:
331.41
Formula:
C15H29N3O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
154039-60-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Rasmussen and McCann (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol.Ther. 75 69. PMID: 9364582.

Wada et al (2003) Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition. Clin.Exp.Metastasis 20 431. PMID: 14524532.

Bjornland et al (2005) Matrix metalloproteinases participate in osteosarcoma invasion. J.Surg.Res. 127 151. PMID: 16083752.

If you know of a relevant citation for this product please let us know.

Keywords: Marimastat, supplier, Broad, spectrum, MMP, inhibitors, Matrix, Metalloprotease, Matrixins, Metalloproteinase, proteinases, proteases, BB2516

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