Cat. No. 2631
Alternative Names: BB 2516, Marimistat
Chemical Name: (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
Biological ActivityBroad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Rasmussen and McCann (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol.Ther. 75 69. PMID: 9364582.
Wada et al (2003) Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition. Clin.Exp.Metastasis 20 431. PMID: 14524532.
Bjornland et al (2005) Matrix metalloproteinases participate in osteosarcoma invasion. J.Surg.Res. 127 151. PMID: 16083752.
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Keywords: Marimastat, supplier, Broad, spectrum, MMP, inhibitors, Matrix, Metalloprotease, Matrixins, Metalloproteinase, proteinases, proteases, BB2516
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