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CGP 71683 hydrochloride

Cat. No. 2199

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Chemical Name: N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride

Biological Activity

Extremely selective, non-peptide NPY Y₅ receptor antagonist. Displays > 1000-fold selectivity over Y₁, Y₂ and Y₄ receptors; IC₅₀ values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y₅, Y₁, Y₂ and Y₄ receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.

Technical Data

M.Wt:

512.07

Formula:

C₂₆H₂₉N₅O₂S.HCl

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

192322-50-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Criscione et al (1998) Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y₅ receptor. J.Clin.Invest. 102 2136. PMID: 9854049.

Dumont et al (2000) Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5). Can.J.Physiol.Pharmacol. 78 116. PMID: 10737674.

Lecklin et al (2002) Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 135 2029. PMID: 11959807.

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Keywords: CGP 71683 hydrochloride, supplier, selective, potent, non-peptide, NPY, Y5, receptor, antagonists, Neuropeptide, Y, Receptors, CGP71683, hydrochloride, neuropeptides

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