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Budesonide

Cat. No. 2671

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Chemical Name: (11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione

Biological Activity

Synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. Reverses DNA hypomethylation and modulates expression of cancer related genes.

Technical Data

M.Wt:

430.53

Formula:

C₂₅H₃₄O₆

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>98 %

Storage:

Store at RT

CAS No:

51333-22-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Spencer et al (1995) Budesonide. A review of its pharmacological properties and therapeutic efficacy in inflammatory bowel disease. Drugs 50 854. PMID: 8586030.

Pereira et al (2006) Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors. Int.J.Cancer 120 1150.

Wattenberg et al (2007) Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice. Cancer Res. 57 5489.

If you know of a relevant citation for this product please let us know.

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Keywords: Budesonide, supplier, Synthetic, glucocorticoid, anti-inflammatory, chemopreventive, Receptors

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