Cat. No. 1548
Chemical Name: (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethy
Biological ActivityNatural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett. 330 283. PMID: 8397101.
Eldridge and Casida (1995) Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice. Toxicol.Appl.Pharmacol. 130 95. PMID: 7839375.
Knapp et al (1999) The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. J.Pharmacol.Exp.Ther. 289 1480. PMID: 10336542.
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Keywords: Cantharidin, supplier, Protein, phosphatase, 1, 2A, inhibitors, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A
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