R&D Systems Inc. Tocris Bioscience Boston Biochem

Cantharidin

Cat. No. 1548

Cantharidin C10H12O4 [56-25-7]

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Chemical Name: (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione

Biological Activity

Natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.

Technical Data

M.Wt:
196.2
Formula:
C10H12O4
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage:
Store at RT
CAS No:
56-25-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett. 330 283. PMID: 8397101.

Eldridge and Casida (1995) Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice. Toxicol.Appl.Pharmacol. 130 95. PMID: 7839375.

Knapp et al (1999) The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. J.Pharmacol.Exp.Ther. 289 1480. PMID: 10336542.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Cantharidin, supplier, Protein, phosphatase, 1, 2A, inhibitors, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A

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