Cat. No. 1548
Chemical Name: (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethy
Biological ActivityNatural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett. 330 283. PMID: 8397101.
Eldridge and Casida (1995) Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice. Toxicol.Appl.Pharmacol. 130 95. PMID: 7839375.
Knapp et al (1999) The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. J.Pharmacol.Exp.Ther. 289 1480. PMID: 10336542.
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Keywords: Cantharidin, supplier, Protein, phosphatase, 1, 2A, inhibitors, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, Protein Ser/Thr Phosphatase Inhibitors