R&D Systems Inc. Tocris Bioscience Boston Biochem

Cantharidin

Cat. No. 1548

Cantharidin C10H12O4 [56-25-7]

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Chemical Name: (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione

Biological Activity

Natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.

Technical Data

M.Wt:
196.2
Formula:
C10H12O4
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Storage:
Store at RT
CAS No:
56-25-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett. 330 283. PMID: 8397101.

Eldridge and Casida (1995) Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice. Toxicol.Appl.Pharmacol. 130 95. PMID: 7839375.

Knapp et al (1999) The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. J.Pharmacol.Exp.Ther. 289 1480. PMID: 10336542.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Cantharidin, supplier, Protein, phosphatase, 1, 2A, inhibitors, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A

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