R&D Systems Inc. Tocris Bioscience Boston Biochem

BMS 191011

Cat. No. 2665

BMS 191011 C16H10ClF3N2O3 [202821-81-6]

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Chemical Name: 3-[(5-Chloro-2-hydroxyphenyl)methyl­]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(­3H)-one

Biological Activity

Potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

Technical Data

M.Wt:
370.71
Formula:
C16H10ClF3N2O3
Solubility:
Soluble to 100 mM in DMSO and to 15 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
202821-81-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Hewawasam et al (2003) Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection. Bioorg.Med.Chem.Letts. 13 1695.

Romine et al (2007) 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR. J.Med.Chem. 50 528. PMID: 17266205.

If you know of a relevant citation for this product please let us know.

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Calcium-Activated Potassium (KCa) Channels
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Keywords: BMS 191011, supplier, Potent, Maxi-K, channel, openers, BKCa, KCa11, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, K+, BMS191011

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