Cat. No. 2660
Alternative Name: R-L3
Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1
Biological ActivityActivator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Salata et al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Am.Soc.Pharmacol.Exp.Ther. 53 220.
Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941. PMID: 14576198.
Jow et al (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443. PMID: 16945016.
Chadha et al (2012) Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 166 1377. PMID: 22251082.
If you know of a relevant citation for this product please let us know.
Keywords: L-364,373, supplier, KCNQ1, KVLQT1, kv7.1, channel, activators, activates, IKs, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, L364373
Find multiple products by catalog number
New Products in this Area
Selective Kir3.1/3.2 (GIRK1/2) channel activatorML 365
Potent and selective TASK-1 channel blockerHMR 1556
Potent and selective Iks channel blockerNS 19504
Activator of BKCa (KCa1.1) channels
May 19 - 22, 2015