Cat. No. 2660
Alternative Name: R-L3
Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one
Biological ActivityActivator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Salata et al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Am.Soc.Pharmacol.Exp.Ther. 53 220.
Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941. PMID: 14576198.
Jow et al (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443. PMID: 16945016.
Chadha et al (2012) Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 166 1377. PMID: 22251082.
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Keywords: L-364,373, supplier, KCNQ1, KVLQT1, kv7.1, channel, activators, activates, IKs, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, L364373
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