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L-364,373

Cat. No. 2660

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Alternative Name: R-L3

Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one

Biological Activity

Activator of K_V7.1 (KCNQ1) channels. Activates the cardiac I_Ks current that decreases action potential duration (APD) in cardiac myocytes.

Technical Data

M.Wt:

397.44

Formula:

C₂₅H₂₀FN₃O

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

103342-82-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Salata et al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K⁺ currents. Am.Soc.Pharmacol.Exp.Ther. 53 220.

Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941. PMID: 14576198.

Jow et al (2006) Rb⁺ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443. PMID: 16945016.

Chadha et al (2012) Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 166 1377. PMID: 22251082.

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Keywords: L-364,373, supplier, KCNQ1, KVLQT1, kv7.1, channel, activators, activates, IKs, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, L364373