BIBO 3304 trifluoroacetateCat No. 2412 |
Price and Availability |
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Chemical Name: N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]me thyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]- a-phenyl-benzeneacetamide ditrifluoroacetate |
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Biological Activity
High affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Wieland et al (1998) Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br.J.Pharmacol. 125 549. Sajdyk et al (1999) Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur.J.Pharmacol. 368 143. Lecklin et al (2002) Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 135 2029.If you know of a useful citation for this product please let us know.
Keywords: BIBO 3304 trifluoroacetate, selective, NPY, Y1, receptor, antagonists, Neuropeptide, Y, Receptors, BIBO3304, trifluoroacetate
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