R&D Systems Inc. Tocris Bioscience Boston Biochem

(±)-Bay K 8644

Cat. No. 1544

()-Bay K 8644 C16H15F3N2O4 [71145-03-4]

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Chemical Name: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester

Biological Activity

L-type Ca2+-channel activator (EC50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. Separate enantiomers (R)-(+)-Bay K 8644 and (S)-(-)-Bay K 8644 also available (Cat. Nos. 1545 and 1546 respectively). In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.

Technical Data

M.Wt:
356.3
Formula:
C16H15F3N2O4
Solubility:
Soluble to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
71145-03-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Greenberg et al (1984) Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes. Brain Res. 305 365. PMID: 6204725.

Bourson et al (1989) Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat. Eur.J.Pharmacol. 160 339. PMID: 2469593.

Shi et al (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3 568. PMID: 18983970.

Sarkar et al (2009) Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 16 46. PMID: 18636076.

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Keywords: ()-Bay K 8644, supplier, Ca2+-channel, activators, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Ca2+, ()-BayK8644

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