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NSC 87877

Cat No. 2613

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Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfon ic acid

Biological Activity

Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC₅₀ values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

Technical Data

M.Wt:

459.45

Formula:

C₁₉H₁₃N₃O₇S₂

Solubility:

Soluble to 50 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

[56990-57-9]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

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Material Safety Data Sheet: View current batch

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References

Chen et al (2006) Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol.Pharmacol. 70 562. Zhao et al (2007) Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 67 1789. Redonde et al (2007) hTRPC1-associated alpha-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J.Thromb.Haemost. 5 2476.

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