NSC 87877

Cat. No. 2613

NSC 87877 C19H13N3O7S2 [56990-57-9]

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Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid

Biological Activity

Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

Technical Data

Soluble to 50 mM in water and to 20 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Chen et al (2006) Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol.Pharmacol. 70 562. PMID: 16717135.

Redonde et al (2007) hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J.Thromb.Haemost. 5 2476. PMID: 17892531.

Zhao et al (2007) Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 67 1789. PMID: 17659592.

If you know of a relevant citation for this product please let us know.

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Keywords: NSC 87877, supplier, Potent, inhibitors, shp2, shp1, PTP, Protein, Tyrosine, Phosphatases, NSC87877, Protein Tyrosine Phosphatase Inhibitors

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