Cat. No. 2613
Chemical Name: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)az
Biological ActivityPotent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Chen et al (2006) Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol.Pharmacol. 70 562. PMID: 16717135.
Redonde et al (2007) hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J.Thromb.Haemost. 5 2476. PMID: 17892531.
Zhao et al (2007) Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 67 1789. PMID: 17659592.
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Keywords: NSC 87877, supplier, Potent, inhibitors, shp2, shp1, PTP, Protein, Tyrosine, Phosphatases, NSC87877