R&D Systems Inc. Tocris Bioscience Boston Biochem

IMD 0354

Cat. No. 2611

IMD 0354 C15H8ClF6NO2 [978-62-1]

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Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

Biological Activity

Inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells.

Technical Data

M.Wt:
383.67
Formula:
C15H8ClF6NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
978-62-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Onai et al (2004) Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Res. 63 51. PMID: 15194461.

Tanaka et al (2005) A novel NF-κB inhibitor, IMD-0354, supresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Hematopoiesis 105 2324.

Tanaka et al (2006) A new IκB kinase β inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Res. 66 419. PMID: 16397257.

If you know of a relevant citation for this product please let us know.

Keywords: IMD 0354, supplier, inhibitors, IKK-2, IKK, IκB, IkappaB, Kinases, Nuclear, Factor, Kappa, B, NF-κB, NF-kappaB, NF-kB, Cytokine, Signaling, Signalling, Transcription, Factors, IMD0354

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