Cat. No. 2611
Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-
Biological ActivityInhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Onai et al (2004) Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Res. 63 51. PMID: 15194461.
Tanaka et al (2005) A novel NF-κB inhibitor, IMD-0354, supresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Hematopoiesis 105 2324.
Tanaka et al (2006) A new IκB kinase β inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Res. 66 419. PMID: 16397257.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: IMD 0354, supplier, inhibitors, IKK-2, IKK, IκB, IkappaB, Kinases, Nuclear, Factor, Kappa, B, NF-κB, NF-kappaB, NF-kB, Cytokine, Signaling, Signalling, Transcription, Factors, IMD0354
Find multiple products by catalog number
New Products in this Area
Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)TC-S 7005
Potent and selective PLK2 inhibitorSRPIN340
Selective SRPK1 inhibitorTC-S 7003
Potent Lck inhibitorML 281
STK33 inhibitorCRT 0066101
Potent protein kinase D (PKD) inhibitorHarmine
Potent and selective Dyrk1A inhibitorAZ 628
Potent Raf kinase inhibitorCHIR 99021 trihydrochloride
Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitorYZ9
PFKFB3 inhibitor; inhibits cell growthKU 0060648
Dual DNA-PK and PI 3-K inhibitorKB SRC 4
Potent and selective c-Src inhibitorProINDY
Dyrk1A/B inhibitor; prodrug of INDY (Cat. No. 4997)INDY
Dyrk1A/B inhibitorAZD 6482
Potent and selective PI 3-Kβ inhibitor
Win a Kindle Fire HD
April 5 - 9, 2014
San Diego CA, USA
Booth Number: 2610