R&D Systems Inc. Tocris Bioscience Boston Biochem

L-R4W2

Cat. No. 1577

L-R4W2 Arg-Arg-Arg-Arg-Trp-Trp-NH2

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Biological Activity

Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.

Technical Data

M.Wt:
1014.2
Formula:
C46H71N21O6
Sequence:
RRRRWW

(Modifications: Trp-6 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
206350-79-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Planells-Cases et al (2000) Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 481 131. PMID: 10996311.

Himmel et al (2002) The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J.Pharmacol.Exp.Ther. 301 981. PMID: 12023528.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: L-R4W2, supplier, TRPV1, antagonists, peptide, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential

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