R&D Systems Inc. Tocris Bioscience Boston Biochem

L-R4W2

Cat. No. 1577

L-R4W2 Arg-Arg-Arg-Arg-Trp-Trp-NH2

Price and Availability

For L-R4W2 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.

Technical Data

M.Wt:
1014.2
Formula:
C46H71N21O6
Sequence:
RRRRWW

(Modifications: Trp-6 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
206350-79-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Planells-Cases et al (2000) Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 481 131. PMID: 10996311.

Himmel et al (2002) The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J.Pharmacol.Exp.Ther. 301 981. PMID: 12023528.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: L-R4W2, supplier, TRPV1, antagonists, peptide, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

Ononetin

TRPM3 blocker

TC-I 2000

TRPM8 blocker

SN 2

Selective TRPML3 channel activator

Sign-up for new product e-alerts
divider line

Tocris Events

Immunology 2014

Immunology 2014

May 2-6, 2014

Pittsburgh, Pennsylvania

Booth Number: 523