Cat. No. 1577
Biological ActivityVanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.
(Modifications: Trp-6 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Planells-Cases et al (2000) Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 481 131. PMID: 10996311.
Himmel et al (2002) The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J.Pharmacol.Exp.Ther. 301 981. PMID: 12023528.
If you know of a relevant citation for this product please let us know.
Keywords: L-R4W2, supplier, TRPV1, antagonists, peptide, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential
Find multiple products by catalog number
New Products in this Area
Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE)ML SA1
Activator of TRPML channelsPhenamil
Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channelsα-Spinasterol
TRPV1 antagonist; displays in vivo activityML 204
Selective TRPC4 blockerA 967079
Selective TRPA1 channel blocker
Win a Kindle
June 12 - 15, 2013
Booth Number: 213