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L-R₄W₂

Cat. No. 1577

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Biological Activity

Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC₅₀ ~ 0.1 μM); blocks Ca²⁺ currents in dorsal root ganglion neurons. Analgesic in vivo.

Technical Data

M.Wt:

1014.2

Formula:

C₄₆H₇₁N₂₁O₆

Sequence:

RRRRWW

(Modifications: Trp-6 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

206350-79-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Planells-Cases et al (2000) Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 481 131. PMID: 10996311.

Himmel et al (2002) The arginine-rich hexapeptide R₄W₂ is a stereoselective antagonist at the vanilloid receptor 1: a Ca²⁺ imaging study in adult rat dorsal root ganglion neurons. J.Pharmacol.Exp.Ther. 301 981. PMID: 12023528.

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