Cat. No. 1571
Alternative Names: Elatericin B, JSI 124
Chemical Name: (9β,10α,16α,23E)-2,16,20,25-Tetrahydro
Biological ActivitySelective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Blaskovich et al (2003) Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63 1270. PMID: 12649187.
Nefedova et al (2005) Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res. 65 9525. PMID: 16230418.
Dziennis et al (2007) Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection. J.Neurosci. 27 7268. PMID: 17611279.
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Keywords: Cucurbitacin I, supplier, Selective, inhibitors, STAT3/JAK2, signaling, signalling, Janus, Activated, Kinase, JAK, Kinases, Signal, Transducers, activators, Transcription, STAT, CucurbitacinI, ElatericinB, JSI124
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December 6 - 10, 2014
Booth Number: 515