Cat. No. 1567
Chemical Name: N-(4,5-Dihydro-4-methyl-5-oxo-1,2-d
Biological ActivityAntibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Jimenez et al (1973) Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 3 729. PMID: 4597739.
O'Neill et al (2000) RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus. Antimicrob.Agents Chemother. 44 3163. PMID: 11036042.
Minamiguchi et al (2001) Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int.J.Cancer 93 307. PMID: 11433393.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Thiolutin, supplier, Bacterial, RNA, polymerases, inhibitors, Antibiotics, vitronectin, cell, Adhesion, Molecules, cam
Find multiple products by catalog number
New Products in this Area
Potent and selective tankyrase inhibitorAbacavir hemisulfate
Reverse transcriptase inhibitor; antiretroviralAzidothymidine
Selective reverse transcriptase inhibitor; antiretroviral
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.