Thiolutin

Cat. No. 1567

Thiolutin C8H8N2O2S2 [87-11-6]

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Chemical Name: N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide

Biological Activity

Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.

Technical Data

M.Wt:
228.28
Formula:
C8H8N2O2S2
Solubility:
Soluble to 5 mg/ml in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
87-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Jimenez et al (1973) Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 3 729. PMID: 4597739.

O'Neill et al (2000) RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus. Antimicrob.Agents Chemother. 44 3163. PMID: 11036042.

Minamiguchi et al (2001) Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int.J.Cancer 93 307. PMID: 11433393.

If you know of a relevant citation for this product please let us know.

Keywords: Thiolutin, supplier, Bacterial, RNA, polymerases, inhibitors, Antibiotics, vitronectin, cell, Adhesion, Molecules, cam

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