R&D Systems Inc. Tocris Bioscience Boston Biochem

Thiolutin

Cat. No. 1567

Thiolutin C8H8N2O2S2 [87-11-6]

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Chemical Name: N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide

Biological Activity

Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.

Technical Data

M.Wt:
228.28
Formula:
C8H8N2O2S2
Solubility:
Soluble in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
87-11-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Jimenez et al (1973) Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 3 729. PMID: 4597739.

O'Neill et al (2000) RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus. Antimicrob.Agents Chemother. 44 3163. PMID: 11036042.

Minamiguchi et al (2001) Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int.J.Cancer 93 307. PMID: 11433393.

If you know of a relevant citation for this product please let us know.

Keywords: Thiolutin, supplier, Bacterial, RNA, polymerases, inhibitors, Antibiotics, vitronectin, cell, Adhesion, Molecules, cam

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