Cat. No. 1559
Alternative Name: EMD 49980
Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-py
Biological ActivityDopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Seyfried et al (1989) Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 dopamine agonist with actions on serotonin systems. Eur.J.Pharmacol. 160 31. PMID: 2565817.
Bartoszyk et al (1996) Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J.Pharmacol.Exp.Ther. 276 41. PMID: 8558454.
Newman-Tancredi et al (1999) Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 359 447. PMID: 10431754.
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Keywords: Roxindole hydrochloride, supplier, 5-HT, reuptake, inhibitors, affinity, 5-HT1A, receptors, D2, dopamine, dopaminergic, agonists, autoreceptor, D3, D4, transporters, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, D2-like, Non-Selective, EMD49980, Non-selective Dopamine Agonists
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High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
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January 12, 2016