R&D Systems Inc. Tocris Bioscience Boston Biochem

Roxindole hydrochloride

Cat. No. 1559

Roxindole hydrochloride C23H26N2O.HCl [108050-82-4]

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Alternative Name: EMD 49980

Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride

Biological Activity

Dopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.

Technical Data

M.Wt:
382.93
Formula:
C23H26N2O.HCl
Solubility:
Soluble to 50 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
108050-82-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Seyfried et al (1989) Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 dopamine agonist with actions on serotonin systems. Eur.J.Pharmacol. 160 31. PMID: 2565817.

Bartoszyk et al (1996) Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J.Pharmacol.Exp.Ther. 276 41. PMID: 8558454.

Newman-Tancredi et al (1999) Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 359 447. PMID: 10431754.

If you know of a relevant citation for this product please let us know.

Keywords: Roxindole hydrochloride, supplier, 5-HT, reuptake, inhibitors, affinity, 5-HT1A, receptors, D2, dopamine, dopaminergic, agonists, autoreceptor, D3, D4, transporters, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, D2-like, Non-Selective, EMD49980

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