R&D Systems Inc. Tocris Bioscience Boston Biochem

Dexmedetomidine hydrochloride

Cat. No. 2749

Dexmedetomidine hydrochloride C13H16N2.HCl [145108-58-3]

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Alternative Name: d-Medetomidine hydrochloride

Chemical Name: 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride

Biological Activity

Active isomer of medetomidine (Cat.No. 5160), a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Technical Data

M.Wt:
236.74
Formula:
C13H16N2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
145108-58-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist. Eur.J.Pharmacol. 150 9. PMID: 2900154.

Scheinin et al (1989) Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635.

Fisher et al (1991) Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur.J.Pharmacol. 192 221. PMID: 1674472.

If you know of a relevant citation for this product please let us know.

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Keywords: Dexmedetomidine hydrochloride, supplier, Active, isomer, α2-Adrenergic, alpha2-Adrenergic, Receptors, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, a2-adrenergic

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