HA14-1

Cat. No. 1541

HA14-1 C17H17BrN2O5 [65673-63-4]

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Chemical Name: 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

Biological Activity

Cell-permeable inhibitor of Bcl-2 protein (IC50 ~ 9 μM); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.

Technical Data

M.Wt:
409.23
Formula:
C17H17BrN2O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
65673-63-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Wang et al (2000) Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc.Natl.Acad.Sci.U.S.A. 97 7124. PMID: 10860979.

Milella et al (2002) Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. Blood 99 3461. PMID: 11964319.

Doshi et al (2006) Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. J.Med.Chem. 49 7731. PMID: 17181155.

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Keywords: HA14-1, supplier, Bcl-2, inhibitors, induces, apoptosis, Bax, Bcl-XL, Mcl-1, Family, bcl2, inhibitor, Tocris Bioscience, Bcl-2 Family Inhibitors

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