R&D Systems Inc. Tocris Bioscience Boston Biochem

HA14-1

Cat. No. 1541

HA14-1 C17H17BrN2O5 [65673-63-4]

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Chemical Name: 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

Biological Activity

Cell-permeable inhibitor of Bcl-2 protein (IC50 ~ 9 μM); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.

Technical Data

M.Wt:
409.23
Formula:
C17H17BrN2O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
65673-63-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Wang et al (2000) Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc.Natl.Acad.Sci.U.S.A. 97 7124. PMID: 10860979.

Milella et al (2002) Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. Blood 99 3461. PMID: 11964319.

Doshi et al (2006) Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. J.Med.Chem. 49 7731. PMID: 17181155.

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View Related Products by Target

Keywords: HA14-1, supplier, Bcl-2, inhibitors, induces, apoptosis, Bax, Bcl-XL, Mcl-1, Family, bcl2, inhibitor

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