Cat. No. 1541
Chemical Name: 2-Amino-6-bromo-α-cyano-3-(ethoxycar
Biological ActivityCell-permeable inhibitor of Bcl-2 protein (IC50 ~ 9 μM); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wang et al (2000) Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc.Natl.Acad.Sci.U.S.A. 97 7124. PMID: 10860979.
Milella et al (2002) Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. Blood 99 3461. PMID: 11964319.
Doshi et al (2006) Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. J.Med.Chem. 49 7731. PMID: 17181155.
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Keywords: HA14-1, supplier, Bcl-2, inhibitors, induces, apoptosis, Bax, Bcl-XL, Mcl-1, Family, bcl2, inhibitor