Cat. No. 1540
Chemical Name: 4-[(2-Butyl-6,7-dichloro-2-cyclopen
Biological ActivityPotent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells (IC50 ~ 2 μM) and ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl- and K+ currents (< 10% inhibition at 10 μM). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Bourke et al (1981) Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative. J.Neurosurg. 55 364. PMID: 6267227.
Decher et al (2001) DCPIB is a novel selective blocker of ICl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br.J.Pharmacol. 134 1467. PMID: 11724753.
Best et al (2004) Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents. Eur.J.Pharmacol. 489 13. PMID: 15063150.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: DCPIB, supplier, Selective, blockers, VSAC, IClswell, volume-sensitive, anion, channels, chloride
Find multiple products by catalog number
New Products in this Area
Potent, voltage-independent CFTR chloride channel inhibitorMonensin sodium salt
Sodium ionophore; antibacterial agent
December 16 - 18, 2014
Booth Number: 12