R&D Systems Inc. Tocris Bioscience Boston Biochem

SB 415286

Cat. No. 1617

SB 415286 C16H10ClN3O5 [264218-23-7]

Price and Availability

For SB 415286 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione

Biological Activity

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
359.73
Formula:
C16H10ClN3O5
Solubility:
Soluble to 25 mM in ethanol and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
264218-23-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Coghlan et al (2000) Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem.Biol. 7 793. PMID: 11033082.

Cross et al (2001) Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J.Neurochem. 77 94. PMID: 11279265.

Liang and Chuang (2006) Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J.Biol.Chem. 282 3904. PMID: 17148450.

If you know of a relevant citation for this product please let us know.

Keywords: SB 415286, supplier, Potent, selective, GSK-3, inhibitors, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, SB415286, GlaxoSmithKline, GSK

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Research Guide

Highlights over 250 products for neurodegeneration research. Request a copy or view PDF today.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Poster

'Schizophrenia - Emerging Targets and Therapeutic Strategies' provides a summary of the targets and pathways representing the most promising strategies to pursue for novel drug development.

divider line

The Neurobiology of Alzheimer's Disease

Written by Alan Palmer

Alzheimer's Poster

'The Neurobiology of Alzheimer's Disease' summarizes structural and functional changes observed in the progression of AD.

divider line

New Product Guide

NPG

Highlights 150 new products added in the second half of 2014. View PDF today.

divider line

New Products in this Area

A12B4C3

Potent and selective polynucleotide kinase/phosphatase (PKNP) inhibitor

BMS 345541

Selective allosteric inhibitor of IKK; anti-inflammatory

WH-4-023

Potent and selective Lck and Src inhibitor; also inhibits SIK

TC-S 7006

Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

OXA 06 dihydrochloride

Potent ROCK inhibitor

PCI 29732

Potent BTK inhibitor

Mps1-IN-1 dihydrochloride

Selective monopolar spindle 1 (Mps1) kinase inhibitor

CKI 7 dihydrochloride

CK1 inhibitor

T 5601640

Selective LIMK2 inhibitor; antitumor

3PO

PFKFB3 inhibitor; antiangiogenic

CHR 6494 trifluoroacetate

Potent and selective haspin kinase inhibitor

UNC 3230

Potent and selective PIP5K1C inhibitor; antinociceptive

trans-ISRIB

Integrated stress response (ISR) inhibitor

BMS 509744

Potent and selective ITK inhibitor

WZ 4003

Potent and selective NUAK1/2 inhibitor

TC-S 7010

Potent and selective Aurora kinase A inhibitor

Bryostatin 2

Protein kinase C activator

ZLN 024 hydrochloride

Allosteric AMPK activator

Temsirolimus

mTOR inhibitor; antitumor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

DPG 2015

Genes and Cancer 2015

April 13 - 15, 2015

Cambridge, UK