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BAY-u 3405

Cat No. 2732

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Alternative Name: Ramatroban

Chemical Name: (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrah ydro-9H-carbazole-9-propanoic acid

Biological Activity

Potent dual antagonist of TP/DP₂ (CRTH2) prostanoid receptors (K_i values are 4.3, 4.5 and > 10000 nM for hDP₂, hTP and hDP₁ receptors respectively). Suppresses PGD₂-induced migration of human eosinophils (IC₅₀ = 170 nM).

Technical Data

M.Wt:

416.47

Formula:

C₂₁H₂₁FN₂O₄S

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Desiccate at -20°C

CAS No:

[116649-85-5]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Sundstrom et al (2003) Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. J.Pharmacol.Exp.Ther. 307 408. Ishizuka et al (2004) Ramatroban (BAY u3405): a novel dual antagonist of TXA₂ receptor and CRTh2, a newly identified prostaglandin D₂ receptor. Cardiovasc.Drug Rev. 22 71. Ulven and Kostenis (2005) Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J.Med.Chem. 48 897.

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Prostanoid Receptors

Keywords: BAY-u 3405, Dual, TP/DP2, CRTH2, receptors, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, BAY-u3405

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