Hemokinin 1 (mouse)
Cat. No. 1535
Alternative Names: HK-1, HEK-1
Biological ActivityNovel mammalian endogenous peptide, homolog of substance P, that is a high affinity and selective agonist at the tachykinin NK1 receptor (Ki values are 0.175 and 560 nM for NK1 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
(Modifications: Met-11 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Zhang et al (2000) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nat.Immunol. 1 392. PMID: 11062498.
Morteau et al (2001) Hemokinin 1 is a full agonist at the substance P receptor. Nat.Immunol. 2 1088. PMID: 11725292.
Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266. PMID: 11786503.
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Keywords: Hemokinin 1 (mouse), supplier, Endogenous, high, affinity, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, Hemokinin1, (mouse)
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