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Icilin

Cat No. 1531

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Alternative Name: AG 3-5

Chemical Name: 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)- pyrimidin-2-one

Biological Activity

Cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK-293 cells (EC₅₀ = 0.36 μM) more potently than menthol or low temperatures. Produces "wet shakes" in vivo.

Technical Data

M.Wt:

311.3

Formula:

C₁₆H₁₃N₃O₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

[36945-98-9]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Wei et al (1983) AG-3-5: a chemical producing sensations of cold. J.Pharm.Pharmacol. 35 110. McKemy et al (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 52. Story et al (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112 819. Behrendt et al (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br.J.Pharmacol. 141 737.

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