R&D Systems Inc. Tocris Bioscience Boston Biochem

GsMTx4

Cat. No. 4912

GsMTx4 Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2

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Biological Activity

Inhibitor of the mechanosensitive TRP channels TRPC1 and TRPC6. Also blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.

Licensing Information

Sold under license from The Research Foundation of The State University of New York

Technical Data

M.Wt:
4095.86
Formula:
C185H273N49O45S6
Sequence:
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF

(Modifications: Disulfide bridge: 2-17,9-23,16-30)

(Modifications: Phe-34 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Suchyna et al (2000) Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J.Gen.Physiol. 115 583. PMID: 10779316.

Bowman et al (2007) Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon. 49 249. PMID: 17157345.

Drew et al (2007) High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One 2 e515. PMID: 17565368.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: GsMTx4, supplier, TRPC, transient, receptor, potential, TRPC1, and, TRPC6, mechanosensitive, ion, channels, MSCs, blockers, blocks, inhibits, inhibitors

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