Cat. No. 4912
Biological ActivityInhibitor of the mechanosensitive TRP channels TRPC1 and TRPC6. Also blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.
Licensing InformationSold under license from The Research Foundation of The State University of New York
(Modifications: Disulfide bridge: 2-17,9-23,16-30)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Suchyna et al (2000) Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J.Gen.Physiol. 115 583. PMID: 10779316.
Bowman et al (2007) Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon. 49 249. PMID: 17157345.
Drew et al (2007) High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One 2 e515. PMID: 17565368.
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Keywords: GsMTx4, supplier, TRPC, transient, receptor, potential, TRPC1, and, TRPC6, mechanosensitive, ion, channels, MSCs, blockers, blocks, inhibits, inhibitors
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July 15, 2014