Cat. No. 4912
Biological ActivityInhibitor of the mechanosensitive TRP channels TRPC1 and TRPC6. Also blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.
Licensing InformationSold under license from The Research Foundation of The State University of New York
(Modifications: Disulfide bridge: 2-17,9-23,16-30)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Suchyna et al (2000) Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J.Gen.Physiol. 115 583. PMID: 10779316.
Bowman et al (2007) Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon. 49 249. PMID: 17157345.
Drew et al (2007) High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One 2 e515. PMID: 17565368.
If you know of a relevant citation for this product please let us know.
Keywords: GsMTx4, supplier, TRPC, transient, receptor, potential, TRPC1, and, TRPC6, mechanosensitive, ion, channels, MSCs, blockers, blocks, inhibits, inhibitors
Find multiple products by catalog number
New Products in this Area
Selective TRPM3 agonistMRS 1477
TRPV1 positive allosteric modulatorMK6-83
TRPML channel activatorTC-I 2014
Potent TRPM8 antagonistASP 7663
Selective TRPA1 activatorRQ 00203078
Potent and selective TRPM8 antagonist; orally active
September 17, 2015