PD 0332991 isethionate

Cat. No. 4786new

PD 0332991 isethionate C24H29N7O2.C2H6O4S [827022-33-3]

Price and Availability

For PD 0332991 isethionate pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Palbociclib

Chemical Name: 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt

Biological Activity

Potent Cdk4/6 inhibitor (IC50 values are 11 and 15 nM for Cdk4 and Cdk6 respectively). Selective for Cdk4/6 over a panel of 34 additional protein kinases (IC50 values are > 10 μM). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines; blocks growth of intracranial glioblastoma multiforme xenografts in mice. Brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 100 mM in water and to 10 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Fry et al (2004) Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol.Cancer Ther. 3 1427. PMID: 15542782.

Toogood et al (2005) Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. J.Med.Chem. 48 2388. PMID: 15801831.

Michaud et al (2010) Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res. 70 3228. PMID: 20354191.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: PD 0332991 isethionate, supplier, PD0332991, isethionate, cyclin, dependent, kinases, Cdk4, Cdk6, selective, potent, inhibitors, inhibits, antitumor, G1, cell, cycle, arrest, brain, penetrant, Cyclin-Dependent Protein Kinase Inhibitors

Quick Order

Find multiple products by catalog number

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Updated in 2015, this guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Cancer Research Product Guide


Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Checkpoint Kinases & the DNA Damage Response

Written by Michelle D. Garrett and Ian Collins

Cell Cycle Life Science Poster

A summary of the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest, senescence and apoptosis. Request copy today.

divider line

New Products in this Area

KG 5

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor


Syk kinase inhibitor; inhibits Aβ production

Centrinone B

High affinity and selective PLK4 inhibitor

HTH 01-015

Potent and selective NUAK1 inhibitor

Kobe 0065

H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling

OSU 03012

PDK1 inhibitor; inhibits Akt signaling

SR 7826

Potent and selective LIMK inhibitor; antitumor

Mps BAY 2a

Potent and selective Mps1 kinase inhibitor

NG 25

TGF-β-activated kinase (TAK1) inhibitor

MI 14

Potent and selective PI 4-kinase IIIβ inhibitor

CTA 056

ITK inhibitor

AZD 1480

Potent and selective JAK2 inhibitor; antiangiogenic

TC-S 7001

Potent and highly selective ROCK inhibitor; orally active

AS 2444697

Potent and selective IRAK4 inhibitor

BS 181 dihydrochloride

Selective cdk7 inhibitor


Potent and selective PI 3-kinase p110α inhibitor

AZ 191

Potent DYRK1B inhibitor

ETP 45658

Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

PFK 15

PFKFB3 inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Pharmacology 2015

Pharmacology 2015

December 15 - 17, 2015

London UK