Cat. No. 4762
Chemical Name: 4-(E)-[[(2Z)-2-cyclohexylimino)-4-m
Biological ActivityInhibitor of Mcl-1; selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Cohen et al (2012) A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem.Biol. 19 1175. PMID: 22999885.
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Keywords: MIM1, supplier, Mcl-1, inhibitors, proapoptotic, induces, apoptosis, caspases, activation
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