Cat. No. 4762
Chemical Name: 4-(E)-[[(2Z)-2-cyclohexylimino)-4-m
Biological ActivityInhibitor of Mcl-1; selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Cohen et al (2012) A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem.Biol. 19 1175. PMID: 22999885.
If you know of a relevant citation for this product please let us know.
Keywords: MIM1, supplier, Mcl-1, inhibitors, proapoptotic, induces, apoptosis, caspases, activation