R&D Systems Inc. Tocris Bioscience Boston Biochem

MIM1

Cat. No. 4762

MIM1 C17H21N3O3S

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Chemical Name: 4-(E)-[[(2Z)-2-cyclohexylimino)-4-methyl-1,3-thiazol-3(2H)-yl]imino]methyl]benzene-1,2,3-triol

Biological Activity

Inhibitor of Mcl-1; selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.

Technical Data

M.Wt:
347.43
Formula:
C17H21N3O3S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Storage:
Store at +4°C

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Cohen et al (2012) A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem.Biol. 19 1175. PMID: 22999885.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: MIM1, supplier, Mcl-1, inhibitors, proapoptotic, induces, apoptosis, caspases, activation

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