R&D Systems Inc. Tocris Bioscience Boston Biochem

Plumbagin

Cat. No. 4761

Plumbagin C11H8O3 [481-42-5]

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Chemical Name: 5-Hydroxy-2-methyl-1,4-naphthalenedione

Biological Activity

Anticancer agent. Induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation; inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Induces intracellular ROS generation in a PI 5-kinase-dependent manner.

Technical Data

M.Wt:
188.18
Formula:
C11H8O3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
481-42-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Hsu et al (2006) Plumbagin (5-hydroxy-2-methyl-1,4-napthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase mediated phosphorylation at serine 15 in vitro and in vivo. J.Pharmacol.Exp.Ther. 318 484. PMID: 16632641.

Kuo et al (2006) Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol.Cancer Ther. 5 3209. PMID: 17172425.

Lee et al (2012) The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation. PLoS One. 7 e45023. PMID: 23028742.

If you know of a relevant citation for this product please let us know.

Keywords: Plumbagin, supplier, anticancer, induces, cell, cycle, arrest, apoptosis, autophagy, cell, death, antiproliferative, p53, phosphorylation, ROS, generation, antitumor

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