Cat. No. 4729
Chemical Name: (3β,5α,22E)-Stigmasta-7.22-dien-3-ol
Biological ActivityTRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258. PMID: 22837009.
If you know of a relevant citation for this product please let us know.
Keywords: a-Spinasterol, supplier, alpha-Spinasterol, α-Spinasterol, antinociceptives, TRPV1, blockers, antagonists, blocks, inhibits, antiedematogenics, in, vivo, brain, penetrant, orally, bioavailable
Find multiple products by catalog number
New Products in this Area
TRPV1 positive allosteric modulatorMK6-83
TRPML channel activatorTC-I 2014
Potent TRPM8 antagonistASP 7663
Selective TRPA1 activatorRQ 00203078
Potent and selective TRPM8 antagonist; orally activeM8 B hydrochloride
Potent and selective TRPM8 channel blocker
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.