R&D Systems Inc. Tocris Bioscience Boston Biochem

α-Spinasterol

Cat. No. 4729

a-Spinasterol C29H48O [481-18-5]

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Chemical Name: (3β,5α,22E)-Stigmasta-7.22-dien-3-ol

Biological Activity

TRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.

Technical Data

M.Wt:
412.69
Formula:
C29H48O
Solubility:
Soluble to 10 mM in ethanol with gentle warming
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
481-18-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258. PMID: 22837009.

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Keywords: a-Spinasterol, supplier, alpha-Spinasterol, α-Spinasterol, antinociceptives, TRPV1, blockers, antagonists, blocks, inhibits, antiedematogenics, in, vivo, brain, penetrant, orally, bioavailable

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