Cat. No. 4729
Chemical Name: (3β,5α,22E)-Stigmasta-7.22-dien-3-ol
Biological ActivityTRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258. PMID: 22837009.
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Keywords: a-Spinasterol, supplier, alpha-Spinasterol, α-Spinasterol, antinociceptives, TRPV1, blockers, antagonists, blocks, inhibits, antiedematogenics, in, vivo, brain, penetrant, orally, bioavailable
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