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LY 215840

Cat. No. 1523

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Chemical Name: [8β(1S,2R)]-N-(2-Hydroxycyclopentyl)-6-methyl-1-(1-methylethyl)-ergoline-8-carboxamide

Biological Activity

5-HT₂/5-HT₇ receptor antagonist. Reduces stimulatory effect of serotonin on aldosterone secretion; also reduces 5-HT-induced cAMP formation (pK_B = 8.26).

Technical Data

M.Wt:

395.54

Formula:

C₂₄H₃₃N₃O₂

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

137328-52-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Cushing et al (1996) LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J.Pharmacol.Exp.Ther. 277 1560. PMID: 8667223.

Lenglet et al (2002) Activation of 5-HT₇ receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels. Endocrinology 143 1748. PMID: 11956157.

Louiset et al (2006) Expression of serotonin7 receptor and coupling of ectopic receptors to protein kinase A and ionic currents in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome. J.Clin.Endocrinol.Metab. 91 4578. PMID: 16954157.

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Keywords: LY 215840, supplier, LY215840, 5-ht, serotonin, receptors, antagonists, 5ht2, 5ht7, 5-hydroxytryptamine

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