Cat. No. 4674
Chemical Name: 5-(2-Amino-8-fluoro[1,2,4]triazolo[
Biological ActivitySelective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bergamini et al (2012) A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nat.Chem.Biol. 8 576. PMID: 22544264.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CZC 24832, supplier, CZC24832, PI3K, PI3-K, PI3kinase, phosphoinositide, 3-kinase, kinases, gamma, inhibitors, inflammation, Tocris Bioscience, PI 3-kinase Inhibitors
Find multiple products by catalog number
New Products in this Area
PKC activator; also NF-κB activatorTBCA
Selective CK2 inhibitorMSC 2032964A
Potent and selective ASK1 inhibitor; orally bioavailableCW 008
PKA signaling activator; promotes osteogenesis from hMSCsPF 06447475
Potent LRRK2 inhibitor; neuroprotectiveAMG PERK 44
Potent and selective PERK inhibitor; orally bioavailableCGP 60474
Potent dual cdk1/cdk2 inhibitorCGP 74514 dihydrochloride
Potent cdk1 inhibitorKG 5
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitorNilvadipine
Syk kinase inhibitor; inhibits Aβ productionCentrinone B
High affinity and selective PLK4 inhibitorHTH 01-015
Potent and selective NUAK1 inhibitorKobe 0065
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signalingOSU 03012
PDK1 inhibitor; inhibits Akt signalingSR 7826
Potent and selective LIMK inhibitor; antitumorMps BAY 2a
Potent and selective Mps1 kinase inhibitorNG 25
TGF-β-activated kinase (TAK1) inhibitorMI 14
Potent and selective PI 4-kinase IIIβ inhibitorCTA 056
ITK inhibitorAZD 1480
Potent and selective JAK2 inhibitor; antiangiogenicTC-S 7001
Potent and highly selective ROCK inhibitor; orally activeAS 2444697
Potent and selective IRAK4 inhibitor
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for AAI 2016.