R&D Systems Inc. Tocris Bioscience Boston Biochem

Elacridar hydrochloride

Cat. No. 4646

Elacridar hydrochloride C34H33N3O5.HCl [143851-98-3]

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Alternative Name: GF 120918

Chemical Name: N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride

Biological Activity

P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
600.1
Formula:
C34H33N3O5.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
143851-98-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Hyafil et al (1993) In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res. 53 4595. PMID: 8402633.

Myer et al (1999) The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line. Oncol Rep. 6 217. PMID: 9864431.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Elacridar hydrochloride, supplier, GF120918, P-glycoprotein, P-gp, inhibitors, multidrug, resistance, MDR, BCRP, ABCG1, ABCG2, ABCB1

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