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LDV FITC

Cat. No. 4577

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Biological Activity

Fluorescent ligand that binds to the α₄β₁ integrin (VLA-4) with high affinity (K_d values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn²⁺ respectively). Used to detect VLA-4 affinity and conformational changes.

Technical Data

M.Wt:

1368.54

Formula:

C₆₉H₈₁N₁₁O₁₇S

Sequence:

LDVPAAK (Modifications: Leu-1 N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-, Lys-6 N-FITC conjugate)

Solubility:

Soluble to 1 mg/ml in 20% acetonitrile / water

Storage:

Store at -20°C

CAS No:

1207610-07-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Chigaev et al (2001) Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn²⁺ or antibody activation. J.Biol.Chem. 276 48670. PMID: 11641394.

Chigaev et al (2003) FRET detection of cellular α₄-integrin conformational activation. Biophys.J. 85 3951. PMID: 14645084.

Njus et al (2009) Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev.Technol. 7 507. PMID: 19754304.

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