Cat. No. 4577
Biological ActivityFluorescent ligand that binds to the α4β1 integrin (VLA-4) with high affinity (Kd values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). Used to detect VLA-4 affinity and conformational changes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Chigaev et al (2001) Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn2+ or antibody activation. J.Biol.Chem. 276 48670. PMID: 11641394.
Chigaev et al (2003) FRET detection of cellular α4-integrin conformational activation. Biophys.J. 85 3951. PMID: 14645084.
Njus et al (2009) Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev.Technol. 7 507. PMID: 19754304.
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Keywords: LDV FITC, supplier, LDVFITC, VLA-4, very, late, antigen, VLA4, integrins, alpha4beta1, a4b1, α, β, fluorescent, ligands
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