Home » Pharmacology » 7-TM Receptors » Peptide Receptors » Calcitonin and Related Receptors » BIBN 4096

BIBN 4096

Cat. No. 4561

Price and Availability

For BIBN 4096 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Olcegepant

Chemical Name: 1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine

Biological Activity

Potent and selective CGRP receptor antagonist (IC₅₀ values are 0.03 and 6.4 nM for human and rat CGRP receptors respectively). Displays high affinity for human CGRP receptors (K_i = 14.4 pM); exhibits no significant affinity for 75 other receptors.

Technical Data

M.Wt:

869.65

Formula:

C₃₈H₄₇Br₂N₉O₅

Solubility:

Soluble to 50 mM in DMSO

Purity:

>96 %

Storage:

Store at -20°C

CAS No:

204697-65-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Doods et al (2000) Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br.J.Pharmacol. 129 420. PMID: 10711339.

Rudolf et al (2005) Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N²-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1- piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)piperazine: the first CGRP antagonist for clinical trials in acute migraine. J.Med.Chem. 48 5921. PMID: 16161996.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Calcitonin and Related Receptors

Peptide Receptors

Keywords: BIBN 4096, supplier, BIBN4096, migraine, potent, selective, CGRP, receptors, antagonists, calcitonin, gene-related, peptides, Olcegepant

Quick Order

Find multiple products by catalog number

Peptide Hormone Receptors Product Listing

Peptide Hormone Receptor Product Listing

Highlights over 200 products for peptide hormone receptors. Reserve your free copy today and be amongst the first to receive it.

Appetite Modulation

Written by Sonia A. Tucci, Lynsay Kobelis & Tim Kirkham. Request a copy or view PDF today.

Gut Hormones and the Regulation of Appetite

Written by V.J. Taylor et al

'Gut Hormones and the Regulation of Appetite' summarizes the neuropeptide modulators and gut hormones that influence appetite

7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy