R&D Systems Inc. Tocris Bioscience Boston Biochem

A 412997 dihydrochloride

Cat. No. 4552

A 412997 dihydrochloride C19H23N3O.2HCl [1347744-96-0]

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Chemical Name: N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide

Biological Activity

Selective agonist for the dopamine D4 receptor (Ki values are 7.9 and 12.1 nM for human D4 and rat D4 receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.

Technical Data

M.Wt:
382.33
Formula:
C19H23N3O.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1347744-96-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Browman et al (2005) A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. Pharmacol.Biochem.Behav. 82 148. PMID: 16154186.

Moreland et al (2005) A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacol.Biochem.Behav. 82 140. PMID: 16153699.

Patel et al (2006) Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J.Med.Chem. 49 7450. PMID: 17149874.

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Keywords: A 412997 dihydrochloride, supplier, A412997, selective, agonists, dopamine, dopaminergic, d4

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