ML 133 hydrochloride
Cat. No. 4549
Chemical Name: N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride
Biological ActivitySelective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 > 300 μM); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Wu et al (2010) A potent and selective small molecule Kir2.1 inhibitor. Probe Reports from the NIH Molecular Libraries Pro. PMID: 21433384.
Wang et al (2011) Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem.Biol. 6 845. PMID: 21615117.
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Keywords: ML 133 hydrochloride, supplier, ML133, hydrochloride, Kir2, Kir2.x, Kir2.1, Kir2.6, Kir2.2, Kir2.3, inhibitors, inward, rectifier, potassium, channels, IRK1, KCNJ2, IRK2, hIRK, IRK3, hIRK2
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