R&D Systems Inc. Tocris Bioscience Boston Biochem

ML 133 hydrochloride

Cat. No. 4549

ML 133 hydrochloride C19H19NO.HCl [1222781-70-5]

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Chemical Name: N-[(4-Methoxyphenyl)methyl]-1-napht­halenemethanamine hydrochloride

Biological Activity

Selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 > 300 μM); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 μM).

Technical Data

M.Wt:
313.82
Formula:
C19H19NO.HCl
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1222781-70-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Wu et al (2010) A potent and selective small molecule Kir2.1 inhibitor. Probe Reports from the NIH Molecular Libraries Pro. PMID: 21433384.

Wang et al (2011) Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem.Biol. 6 845. PMID: 21615117.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Inward Rectifier Potassium (Kir) Channels
Potassium Channels

Keywords: ML 133 hydrochloride, supplier, ML133, hydrochloride, Kir2, Kir2.x, Kir2.1, Kir2.6, Kir2.2, Kir2.3, inhibitors, inward, rectifier, potassium, channels, IRK1, KCNJ2, IRK2, hIRK, IRK3, hIRK2

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