Cat. No. 4545
Chemical Name: (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-m
Biological ActivityInhibitor of cathepsins B and L; also thought to inhibit calpain. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with pepstatin A (Cat. No. 1190). Lysosome and cell permeable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Wilcox and Mason (1992) Inhibition of cysteine proteinases in lysosomes and whole cells. Biochem.J. 285 495. PMID: 1637341.
Tanada et al (2005) Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1 84. PMID: 16874052.
Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677. PMID: 17942897.
Kim et al (2008) Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 4 659. PMID: 18424912.
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Keywords: E 64d, supplier, lysosomal, proteases, inhibitors, cathepsins, autophagy, autolysosomal, digestion, E64d
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July 23 - 27, 2014
Bonn University, Germany