Cat. No. 4545
Chemical Name: (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-m
Biological ActivityInhibitor of cathepsins B and L; also thought to inhibit calpain. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with pepstatin A (Cat. No. 1190). Lysosome and cell permeable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Wilcox and Mason (1992) Inhibition of cysteine proteinases in lysosomes and whole cells. Biochem.J. 285 495. PMID: 1637341.
Tanada et al (2005) Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1 84. PMID: 16874052.
Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677. PMID: 17942897.
Kim et al (2008) Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 4 659. PMID: 18424912.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: E 64d, supplier, lysosomal, proteases, inhibitors, cathepsins, autophagy, autolysosomal, digestion, E64d
Find multiple products by catalog number
New Products in this Area
Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitorAprotinin
Competitive serine protease inhibitorTCID
Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor2-MPPA
Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailableE 64
Potent and irreversible cysteine protease inhibitorAEBSF
Broad spectrum, irreversible inhibitor of serine proteasesTC-E 5006
γ-secretase modulator; reduces Aβ42 levelsPTIQ
Potent MMP-3 expression inhibitor; neuroprotective
November 15 - 19, 2014
Washington D.C., USA