Cat. No. 4541
Chemical Name: 1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-
Biological ActivityHighly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1.
Licensing InformationThis probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 0946 probe summary on the SGC website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Yu et al (2012) Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat.Commun. 3 1288. PMID: 23250418.
If you know of a relevant citation for this product please let us know.
Keywords: SGC 0946, supplier, SGC0946, epigenetics, DOT1L, histone, protein, methyltransferase, PKMTs, H3K79me, potent, selective, inhibitors, inhibits, leukemia, MLL, target, genes
Find multiple products by catalog number
New Products in this Area
N-acetyltransferase 10 (NAT10) inhibitorEPZ 004777
Highly potent DOT1L inhibitorOICR 9429
High affinity and selective WDR5 antagonistMM 102
WDR5/MLL interaction inhibitorUNC 2327
Allosteric inhibitor of PRMT3GSK 2194069
Potent human fatty acid synthase (hFAS) inhibitorFuramidine dihydrochloride
Selective PRMT1 inhibitorXY1
Negative control of SGC 707 (Cat. No. 5367)SGC 707
Potent and selective allosteric inhibitor of PRMT3
Tocris Product News
SGC Epigenetic Probes
Introducing our new epigenetics probes provided in collaboration with the Structural Genomics Consortium (SGC).