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Phalloidin

Cat. No. 4535

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Biological Activity

Promotes actin polymerization. Decreases dissociation rate constant for actin subunits from filament ends; lowers critical concentration for polymerization.

Technical Data

M.Wt:

788.87

Formula:

C₃₅H₄₈N₈O₁₁S

Sequence:

ATCXAWL (Modifications: Cyclic Cys-3-Trp-6, X=Hyp, D-Thr-2)

Solubility:

Soluble to 1 mg/ml in water

Storage:

Store at -20°C

CAS No:

17466-45-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Wehland et al (1977) Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth. Proc.Natl.Acad.Sci.USA 74 5613. PMID: 341163.

Coluccio and Tilney (1984) Phalloidin enhances actin assembly by preventing monomer dissociation. J.Cell Biol. 99 529. PMID: 6746738.

Cooper (1987) Effects of cytochalasin and phalloidin on actin. J.Cell Biol. 105 1473. PMID: 3312229.

Diensthuber et al (2011) Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin. FEBS Lett. 585 767. PMID: 21295570.

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