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VUF 10166

Cat. No. 4532

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Chemical Name: 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline

Biological Activity

High affinity 5-HT₃ receptor antagonist (IC₅₀ values are 0.04 and 22 nM for human 5HT_3A and 5-HT_3AB receptors respectively). Exhibits partial agonist activity at 5-HT_3A receptors at higher concentrations (EC₅₀ = 5.2 μM). Also histamine H₄ receptor antagonist (pK_i = 6.64 in HEK cells).

Technical Data

M.Wt:

262.74

Formula:

C₁₃H₁₅ClN₄

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at RT

CAS No:

155584-74-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Smits et al (2008) Fragment based design of new H₄ receptor-ligands with anti-inflammatory properties in vivo. J.Med.Chem. 51 2457. PMID: 18357976.

Thompson et al (2012) VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors. J.Pharmacol.Exp.Ther. 341 350. PMID: 22306960.

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