Cat. No. 4532
Chemical Name: 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline
Biological ActivityHigh affinity 5-HT3 receptor antagonist (IC50 values are 0.04 and 22 nM for human 5HT3A and 5-HT3AB receptors respectively). Exhibits partial agonist activity at 5-HT3A receptors at higher concentrations (EC50 = 5.2 μM). Also histamine H4 receptor antagonist (pKi = 6.64 in HEK cells).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Smits et al (2008) Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J.Med.Chem. 51 2457. PMID: 18357976.
Thompson et al (2012) VUF10166, a novel compound with differing activities at 5-HT3A and 5-HT3AB receptors. J.Pharmacol.Exp.Ther. 341 350. PMID: 22306960.
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Keywords: VUF 10166, supplier, 5-ht, serotonin, receptors, antagonists, high, affinity, partial, agonists, 5-ht3a, 5-ht3ab, 5-ht3, 5ht, VUF10166
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